Article

Design of diverse, functional mitochondrial targeting sequences across eukaryotic organisms using variational autoencoder

2024-08-29

Abstract excerpt

Mitochondria play a key role in energy production and cellular metabolism, making them a promising target for metabolic engineering and disease treatment. However, despite the known influence of passenger proteins on localization efficiency, only a few protein-localization tags have been characterized for mitochondrial targeting. To address this limitation, we exploited Variational Autoencoder (VAE), an unsupervis...

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Literature Corpus work: 9dd876e2-34c4-5d10-ade3-4ca219076135
DOI: 10.1101/2024.08.28.610205

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