Article

TargetMITO: A rule-based model for generating highly functional synthetic mitochondrial targeting sequence in yeast

2026-02-23

Abstract excerpt

Mitochondria are essential organelles containing their own genomes, encoding a few proteins essential for energy production. Most of the mitochondrial proteins are nucleus-encoded, translated as precursors in the cytoplasm, with a large fraction of these precursors properly addressed by an N-terminal mitochondrial targeting sequence (MTS). These MTS share common features but no consensus sequence can explain their...

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Literature Corpus work: 7a9a81b4-91c1-5a5b-9297-4742141c94dc
DOI: 10.64898/2026.02.22.707306

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