Article

PSMC-FAC: A Statistical Framework for Correcting Loss of Heterozygosity in Low-Coverage Genomic Demographic Inference

2026-03-09

Abstract excerpt

Inferring demographic history from whole-genome data is a fundamental objective in evolutionary and conservation genomics. However, the Pairwise Sequentially Markovian Coalescent (PSMC) framework, the most widely used demographic inference method for whole-genome sequence data, is highly sensitive to sequencing coverage, with low coverage producing systematic underestimation of heterozygosity and biased effective...

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Literature Corpus work: 9dcdb28e-02fb-55cd-8305-f381f55522af
DOI: 10.20944/preprints202603.0681.v1

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