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Article

Can genomic analysis actually estimate past population size?

Trends in genetics : TIG - 1 Jul 2025

Bansal Janeesh K, Nichols Richard A

Abstract excerpt

Genomic data can be used to reconstruct population size over thousands of generations, using a new class of algorithms [sequentially Markovian coalescent (SMC) methods]. These analyses often show a recent decline in Ne (effective size), which at face value implies a conservation or demographic crisis: a population crash and loss of genetic diversity. This interpretation is frequently mistaken. Here we outline how...

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PMID: 40280846
DOI: 10.1016/j.tig.2025.03.003

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