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Article

Ancestral population genomics: the coalescent hidden Markov model approach.

Genetics - 1 Sept 2009

Dutheil Julien Y, Ganapathy Ganesh, Hobolth Asger, Mailund Thomas, Uyenoyama Marcy K, Schierup Mikkel H

Abstract excerpt

With incomplete lineage sorting (ILS), the genealogy of closely related species differs along their genomes. The amount of ILS depends on population parameters such as the ancestral effective population sizes and the recombination rate, but also on the number of generations between speciation events. We use a hidden Markov model parameterized according to coalescent theory to infer the genealogy along a...

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Identifiers

PMID: 19581452
DOI: 10.1534/genetics.109.103010
PMCID: PMC2746150

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