Article

Elevated phosphate mediates extensive cellular toxicity: from abnormal proliferation to excessive cell death

2020-01-02

Abstract excerpt

Inorganic phosphate (Pi) is an essential nutrient for human health. Due to our change in dietary pattern, dietary Pi overload engenders systematic phosphotoxicity, including excessive Pi related vascular calcification and chronic tissue injury. The molecular mechanisms of the seemingly distinct phenotypes remain elusive. In this study, we found that Pi directly mediates diverse cellular toxicity in a dose-dependen...

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Literature Corpus work: 9db18ad9-064c-5f4c-9bdf-e092af8793c1
DOI: 10.1101/2020.01.02.892638

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