Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney Cysts

29 Mar 2017

Abstract excerpt

The members of the PhosphoInositide-3 Kinase (PI3K) protein family are well-known regulators of proliferative signals. By the generation of lipid second messengers, they mediate the activation of AKT/PKB (AKT) and mammalian Target Of Rapamycin (mTOR) pathways. Although mutations in the PI3K/AKT/mTOR pathway are highly characterized in cancer, recent evidence indicates that alterations in the proliferative signals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Kidney Cyst Diseases
Share to Renal and related cancers
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28353628
DOI: 10.3390/cancers9040030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PI3K Signaling in Tissue Hyper-Proliferation: From Overgrowth Syndromes to Kidney CystsPMID 28353628Read ↗

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies.Semantic proximity Read ↗

PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.Semantic proximity Read ↗

The PTEN–PI3K Axis in CancerSemantic proximity Read ↗

Updates on Diagnosis and Treatment of PIK3CA-Related Overgrowth Spectrum.Semantic proximity Read ↗

The PTEN-PI3K Axis in CancerSemantic proximity Read ↗

Treatment strategies for mosaic overgrowth syndromes of the PI3K-AKT-mTOR pathway.Semantic proximity Read ↗

When overgrowth bumps into cancer: the PTEN-opathies.Semantic proximity Read ↗

Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities.Semantic proximity Read ↗

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.Semantic proximity Read ↗

Clinical and functional characterization of germline PIK3CA variants in patients with PIK3CA-related overgrowth spectrum disorders.Semantic proximity Read ↗

PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic DiseasesSemantic proximity Read ↗

mTOR signaling in polycystic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.