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Sex Differences in Colorectal Cancer: Epidemiology, Risk Factors, and Clinical Outcomes

6 Aug 2025

Abstract excerpt

Colorectal cancer (CRC) constitutes a major global health concern, ranking as the third most common cancer and the second leading cause of cancer-related mortality. The current review explores sex-based differences in CRC epidemiology, risk factors, tumor biology, and clinical outcomes. Males exhibit a higher incidence and mortality rate, with left-sided (distal) CRC predominating, while females are more...

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PMID: 40807160
DOI: 10.3390/jcm14155539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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