Article

The inflammasome adaptor protein ASC promotes amyloid deposition in Cryopyrin-associated Periodic Syndromes

2024-11-12

Abstract excerpt

<title>Abstract</title> <p>Amyloid A (AA)-type amyloidosis is a complication associated with various autoinflammatory diseases, including cryopyrin-associated periodic syndromes (CAPS). The activation of the NLRP3-inflammasome in CAPS leads to the release of inflammasome oligomers, which are primarily composed of oligomeric filaments of the protein ASC. Recent studies have demonstrated that extracellular depositi...

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Literature Corpus work: 9d410298-b008-51b4-b92f-1b90f72d167f
DOI: 10.21203/rs.3.rs-5416087/v1

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