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Native CRISPR-Cas mediated in situ genome editing reveals the exquisite interplay of resistance mutations in clinical multidrug resistant Pseudomonas aeruginosa

2018-12-17

Abstract excerpt

Antimicrobial resistance (AMR) is imposing a global public health threat. Despite its importance, resistance characterization in the native background of clinically isolated resistant pathogens is frequently hindered by the lack of genome editing tools in these "non-model" strains. Pseudomonas aeruginosa is both a prototypical multidrug resistant (MDR) pathogen and a model species for understanding CRISPR-Cas func...

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Literature Corpus work
9d350929-cf4e-5aa1-ac25-398f47ea4b41
DOI
10.1101/496711
Open publication

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Native CRISPR-Cas mediated in situ genome editing reveals the exquisite interplay of resistance mutations in clinical multidrug resistant Pseudomonas aeruginosaDOI 10.1101/496711
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