Article
Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics.
The Journal of molecular diagnostics : JMD - 1 Jul 2021
Roepman Paul, de Bruijn Ewart, van Lieshout Stef, Schoenmaker Lieke, Boelens Mirjam C, Dubbink Hendrikus J, Geurts-Giele Willemina R R, Groenendijk Floris H, Huibers Manon M H, Kranendonk Mariëtte E G, Roemer Margaretha G M, Samsom Kris G, Steehouwer Marloes, de Leng Wendy W J, Hoischen Alexander, Ylstra Bauke, Monkhorst Kim, van der Hoeven Jacobus J M, Cuppen Edwin
Abstract excerpt
Whole genome sequencing (WGS) using fresh-frozen tissue and matched blood samples from cancer patients may become the most complete genetic tumor test. With the increasing availability of small biopsies and the need to screen more number of biomarkers, the use of a single all-inclusive test is preferable over multiple consecutive assays. To meet high-quality diagnostics standards, we optimized and clinically...
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