Article

Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals

2022-10-26

Abstract excerpt

<title>Abstract</title> <p>We aimed to investigate the relationship between spatiotemporal changes of amyloid deposition and Alzheimer's disease (AD) profiles in cognitively normal (CN) and those with mild cognitive impairment (MCI). Using a data-driven method and amyloid-PET data, we identified and validated two subtypes in two independent datasets (discovery dataset: N = 548, age = 72.4 ± 6.78, 49% female; vali...

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Literature Corpus work: 9cf62912-46d3-5e24-b2b8-e17ec8f874e8
DOI: 10.21203/rs.3.rs-2083710/v1

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