Article

Hypoxic potentiation of cytoskeleton prevents oncogene-induced senescence

2022-11-30

Abstract excerpt

<title>Abstract</title><p>Expression of oncogenes in human primary cells triggers oncogene-induced senescence (OIS). Distinct from other types of senescence, OIS induces dramatic changes in nuclear shape, cytoskeleton, and heterochromatin distribution. We found that ectopic expression of the<italic>ΔB-Raf</italic>oncogene in IMR90 human fibroblasts induced rearrangement of heterochromatin accompanied by weakening...

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Literature Corpus work: 9cd1a0e0-43d0-5875-bd03-1f0fd10cabc8
DOI: 10.21203/rs.3.rs-2137207/v1

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