Article

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike Glycoprotein

2021-04-26

Abstract excerpt

<h4>ABSTRACT</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon binding of its spike (S) glycoproteins to ACE2 receptors. Several nanobodies neutralize SARS-CoV-2 infection by binding to the receptor-binding domain (RBD) of S protein, but the underlying mechanism is not well understood. Here, we identified an extended network of pairwise interactions between RBD and nanobodi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c98aceb-43ae-5cda-aa95-a3f085998444
DOI: 10.1101/2021.04.23.441186

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Binding mechanism of neutralizing Nanobodies targeting SARS-CoV-2 Spike GlycoproteinDOI 10.1101/2021.04.23.441186Read

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2Semantic proximity Read

Binding Interactions between RBD of Spike-Protein and Human ACE2 in Omicron variantSemantic proximity Read

Unraveling the stability landscape of mutations in the SARS-CoV-2 receptor-binding domainSemantic proximity Read

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSemantic proximity Read

A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drugSemantic proximity Read

SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors.Semantic proximity Read

Molecular Insights into the Variability in Infection and Immune Evasion Capabilities of SARS-CoV-2 Variants: A Sequence and Structural Investigation of the RBD Domain.Semantic proximity Read

Peptide derived nanobody inhibits entry of SARS-CoV-2 variantsSemantic proximity Read

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spikeSemantic proximity Read

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spikeSemantic proximity Read

Structural perspective of the interactions of ACE2 and SARS CoV-2 Spike protein RBDSemantic proximity Read

Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant.Semantic proximity Read