Article

Detecting weak signals by combining small P-values in genetic association studies

2019-06-11

Abstract excerpt

We approach the problem of combining top-ranking association statistics or P-values from a new perspective which leads to a remarkably simple and powerful method. Statistical methods, such as the Rank Truncated Product (RTP), have been developed for combining top-ranking associations and this general strategy proved to be useful in applications for detecting combined effects of multiple disease components. To incr...

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Literature Corpus work: 9c752832-e62b-5be0-a1ff-2e2d8cf3b08f
DOI: 10.1101/667238

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