Article

Structural insight into T cell coinhibition by PD-1H (VISTA)

2020-01-09

Abstract excerpt

Programmed death-1 homolog (PD-1H), a CD28/B7 family molecule, coinhibits T cell activation and is an attractive immunotherapeutic target for cancer and inflammatory diseases. The molecular basis of its function, however, is unknown. Bioinformatic analyses indicated that PD-1H has a very long Ig variable region (IgV)-like domain and extraordinarily high histidine content, suggesting that unique structural features...

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Literature Corpus work: 5088fde1-d005-5ac4-84bc-43ffa1b6cd6c
DOI: 10.1073/pnas.1908711117

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