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Mutation of <i>kvrA</i> causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing <i>Klebsiella pneumoniae</i>

2019-11-17

Abstract excerpt

Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK36 porin. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae . The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor that controls capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36...

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Literature Corpus work
9c4ba752-78eb-54b3-a081-7a333a893e26
DOI
10.1101/845925
Open publication

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Mutation of <i>kvrA</i> causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing <i>Klebsiella pneumoniae</i>DOI 10.1101/845925
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