Article
A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy - 8 Oct 2024
Yasmin Mohamad, Marshall Steven H, Chen Liang, Rhoads Daniel D, Jacobs Michael R, Rojas Laura J, Perez Federico, Hujer Andrea M, Hujer Kristine M, van Duin David, Fowler Vance, Chambers Henry F, Kreiswirth Barry N, Bonomo Robert A
Abstract excerpt
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased blaKPC copy numbers. KPC-KP...
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