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Article

Functional export of NDM-7 to outer membrane vesicles in <i>Klebsiella pneumoniae</i> compromises imipenem and cefiderocol activity

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> The carbapenemases KPC and NDM are the most widespread determinants of carbapenem resistance in Klebsiella pneumoniae . Whereas KPC is a soluble periplasmic serine-β-lactamase, NDM is a membrane-anchored metallo-β-lactamase (MBL), a feature that promotes its incorporation into outer membrane vesicles (OMVs). OMVs are naturally released nanoparticles that deliver diverse bioactive cargo, includi...

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Literature Corpus work
e6220e06-a5c1-59c2-8107-088a78fd04d4
DOI
10.64898/2026.06.26.734736
Open publication

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