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<i>Klebsiella pneumoniae</i> mutants resistant to ceftazidime/avibactam plus aztreonam, imipenem/relebactam, meropenem/vaborbactam and cefepime/taniborbactam

2021-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Using modified Klebsiella pneumoniae clinical isolates, we show that ramR plus ompK36 mutation together with production of the V239G variant KPC-3 confirs resistance to ceftazidime/avibactam plus aztreonam, imipenem/relebactam and meropenem/vaborbactam, but not cefepime/taniborbactam. This is because the V239G variant does not generate collateral β-lactam susceptibility as do many other KPC-3...

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Literature Corpus work
55aef880-0f11-5cf1-9318-194a6c2e2ba7
DOI
10.1101/2021.11.21.469431
Open publication

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<i>Klebsiella pneumoniae</i> mutants resistant to ceftazidime/avibactam plus aztreonam, imipenem/relebactam, meropenem/vaborbactam and cefepime/taniborbactamDOI 10.1101/2021.11.21.469431
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