Article
Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis.
Endocrinology - 1 Mar 2006
Li Xiangdong, Strauss Leena, Kaatrasalo Annukka, Mayerhofer Artur, Huhtaniemi Ilpo, Santti Risto, Mäkelä Sari, Poutanen Matti
Abstract excerpt
Our previous studies have shown that transgenic male mice expressing human P450 aromatase (AROM+) are infertile. In the present study, we followed the testis phenotype up to 15 months of age in these mice. The testes of the old AROM+ mice showed Leydig cell hypertrophy and hyperplasia, as indicated by the staining for steroidogenic enzymes and androgen and estrogen receptors. However, the Leydig cell adenomas did...
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