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Article

Plasma metabolites as mediators in the relationship between inflammation-related proteins and benign prostatic hyperplasia: insights from mendelian randomization.

Scientific reports - 30 Oct 2024

Cui Yan, Wang Hui, Wang Yuting

Abstract excerpt

Benign prostatic hyperplasia (BPH) is a condition commonly observed in aging males. Inflammatory and metabolic factors are pivotal in the development and progression of BPH. The degree to which the effects of 91 inflammation-related proteins on BPH are mediated by 1400 plasma metabolites remains ambiguous. Our research analyzed the impact of these traits utilizing genetic evidence.Two-sample Mendelian...

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Inflammation
Interleukin-2
Lysine
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Prostatic Hyperplasia

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PMID: 39478098
DOI: 10.1038/s41598-024-77515-2
PMCID: PMC11525667

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