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Article

Structural characterization of the human CC2D1A fragment associated with non-syndromic intellectual disability (NSID).

Bioscience reports - 17 Jun 2026

Yeh Yi-Hung, Lin Min-Guan, Sun Xing-Han, Shen Yo-You, Ling Pin, Hsiao Chwan-Deng

Abstract excerpt

CC2D1A is a multidomain scaffold protein implicated in transcriptional regulation and autosomal recessive non-syndromic intellectual disability (NSID), yet its molecular mechanism is still poorly understood due to a lack of structural information. Here, we present the crystal structure of the human CC2D1A491-810 fragment, encompassing the fourth DM14 domain, a coiled-coil region, and a C-terminal C2 domain. These...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42047282
DOI: 10.1042/BSR20253955
PMCID: PMC13199796

Genes

C2
CC2D1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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