Article

Characterisation of the interleukin-4 signalling cascade involved in the induction of cyclooxygenase-2 and the polarisation of macrophages into an anti-inflammatory phenotype

2018-01-01

Abstract excerpt

The inflammatory response can be broken down into the pro-inflammatory phase, followed by the resolution phase. Both phases are regulated by the expression or release of immunomodulatory mediators such as cytokines e.g. TNFα and IL-10. The two phases are also associated with different macrophage polarization states where the M1 phenotype is seen during the pro-inflammatory phase and M2 during resolution. Whereas m...

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Literature Corpus work: 9bd006ad-9d85-5cfc-8c58-5e61664b2dba
DOI: 10.15123/pub.7382

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