Article

Machine learning prediction and phyloanatomic modeling of viral neuroadaptive signatures in the macaque model of HIV-mediated neuropathology

2022-06-17

Abstract excerpt

In human immunodeficiency virus (HIV) infection, virus replication in the central nervous system (CNS) can result in HIV-associated neurocognitive deficits in approximately 25% of patients with unsuppressed viremia and is thought to be characterized by evolutionary adaptation to this unique microenvironment. While no single mutation can be agreed upon as distinguishing the neuroadapted population from virus in pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bcc61f2-00f8-5cf4-8446-f3a4398e245a
DOI: 10.1101/2022.06.17.496109

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine learning prediction and phyloanatomic modeling of viral neuroadaptive signatures in the macaque model of HIV-mediated neuropathologyDOI 10.1101/2022.06.17.496109Read

Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?Semantic proximity Read

Prediction of HIV-associated neurocognitive disorder (HAND) from three genetic features of envelope gp120 glycoproteinSemantic proximity Read

Genetic attributes of cerebrospinal fluid-derived HIV-1 env.Semantic proximity Read

The Genetic Fingerprint of HIV in the Brain: Insights into Neurocognitive DysfunctionSemantic proximity Read

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates.Semantic proximity Read

Machine Learning Approaches to Understand Cognitive Phenotypes in People With HIV.Semantic proximity Read

Cognitive Phenotypes of HIV Defined Using a Novel Data-driven Approach.Semantic proximity Read

Phylogenetics and Phyloanatomy of HIV/SIV Intra-Host Compartments and Reservoirs: The Key Role of the Central Nervous SystemSemantic proximity Read

Pathogenesis of SIV encephalitis. Selection and replication of neurovirulent SIV.Semantic proximity Read

Laser Capture Microdissection Assessment of Virus Compartmentalization in the Central Nervous Systems of Macaques Infected with Neurovirulent Simian Immunodeficiency VirusSemantic proximity Read

Neuropathogenic SIVsmmFGb genetic diversity and selection-induced tissue-specific compartmentalization during chronic infection and temporal evolution of viral genes in lymphoid tissues and regions of the central nervous system.Semantic proximity Read

Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis, and Poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targetsSemantic proximity Read