Article

Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis, and Poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets

2020-05-24

Abstract excerpt

<h4>Background</h4> Despite improvements in antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders (HAND) remain prevalent in subjects undergoing therapy. HAND significantly affects individuals’ quality of life, as well as adherence to therapy, and, despite the increasing understanding of neuropathogenesis, no definitive diagnostic or prognostic marker has been ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 132ef2d4-3c11-5c88-b493-dd6cf054e0f2
DOI: 10.1101/2020.05.21.109140

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis, and Poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targetsDOI 10.1101/2020.05.21.109140Read

Brain tissue transcriptomic analysis of SIV-infected macaques identifies Poly (ADP-ribose) polymerases (PARPs) as potential biomarkers for neuropathogenesis.Semantic proximity Read

Central nervous system (CNS) transcriptomic correlates of human immunodeficiency virus (HIV) brain RNA load in HIV-infected individualsSemantic proximity Read

HIV-Associated Neurocognitive Disorder (HAND) Biomarker Identification: Significance Analysis of Microarrays and Two Persuasive Approaches with Random ForestSemantic proximity Read

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive DisordersSemantic proximity Read

Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disordersSemantic proximity Read

Gene expression patterns associated with neurological disease in human HIV infectionSemantic proximity Read

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaquesSemantic proximity Read

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain RegionsSemantic proximity Read

Single-Cell Multi-Modal Differential Analysis of the Human Neo-Cortex in HIV Infection Reveals Similarities with Hallmarks of Alzheimer’s DiseaseSemantic proximity Read

Genomic Factors and Therapeutic Approaches in HIV-Associated Neurocognitive Disorders: A Comprehensive ReviewSemantic proximity Read

Neuroinflammatory transcriptional programs induced in rhesus pre-frontal cortex white matter during acute SHIV infectionSemantic proximity Read

Neurological impact of HIV/AIDS and substance use alters brain function and structureSemantic proximity Read