Article

Triptolide-induced apoptosis in p53 mutant hepatoma cells involves ROS-mutant p53- dependent inhibition effect on p21 expression

2022-05-18

Abstract excerpt

Chemotherapeutic drugs had poor cytotoxic effects on cancer cells with mutation in the p53 gene. However, triptolide induced apoptosis in tumor cells with mutant (mt) p53. Here we study the potential therapeutic effects and underlying mechanisms of triptolide against human liver cancer cells bearing mt p53. One hepatic cancer cell line with mt p53 (Huh7) and another p53-deficient hepatic cancer cell line (Hep3B) w...

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Literature Corpus work: 9b55a820-34c2-5e85-8d11-58ed832d8426
DOI: 10.21203/rs.3.rs-1660055/v1

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