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Article

Selective induction of tumor cell apoptosis by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl) propiolate.

The Journal of biological chemistry - 29 Mar 2013

Sun Xiaoxiao, Ai Midan, Wang Ying, Shen Shensi, Gu Yuan, Jin Yi, Zhou Zuyu, Long Yaqiu, Yu Qiang

Abstract excerpt

Induction of tumor cell apoptosis has been recognized as a valid anticancer strategy. However, therapeutic selectivity between tumor and normal cells has always been a challenge. Here, we report a novel anti-cancer compound methyl 3-(4-nitrophenyl) propiolate (NPP) preferentially induces apoptosis in tumor cells through P450-catalyzed reactive oxygen species (ROS) production. A compound sensitivity study on...

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Identifiers

PMID: 23382387
DOI: 10.1074/jbc.M112.429316
PMCID: PMC3610958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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