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Article

Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas.

Medical oncology (Northwood, London, England) - 1 Jul 2014

Wu Jianyuan, Li Qingdi Quentin, Zhou Huiping, Lu Yinying, Li Jueli M, Ma Yao, Wang Li, Fu Tingting, Gong Xingjiang, Weintraub Michael, Wu Shuangchan, Ding Hong

Abstract excerpt

Triptolide is a traditional Chinese medicinal herb-derived antineoplastic agent. However, its antitumor activity against gynecologic carcinomas has not yet been well described. It is the purpose of this article to investigate the effect and mechanism of triptolide in human ovarian cancer using both A2780 (p53 wild) and OVCAR-3 (p53 mutated) cells. Our results showed that triptolide exerted a potent inhibitory...

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PMID: 24880464
DOI: 10.1007/s12032-014-0014-8

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