Article

CRISPR base editing of <i>cis</i> -regulatory elements enables target gene perturbations

2022-05-26

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR technology has demonstrated broad utility for controlling target gene expression; however, there remains a need for strategies capable of modulating expression via the precise editing of non-coding regulatory elements. Here we demonstrate that CRISPR base editors, a class of gene-modifying proteins capable of creating single-base substitutions in DNA, can be used to perturb gene expressio...

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Identifiers and source

Literature Corpus work: 80240678-797d-5cd9-acaf-eb7f0aa777af
DOI: 10.1101/2022.05.26.493649

Open publication

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