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Article

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages.

Molecular microbiology - 1 Jan 2009

Schnick Claudia, Polley Spencer D, Fivelman Quinton L, Ranford-Cartwright Lisa C, Wilkinson Shane R, Brannigan James A, Wilkinson Anthony J, Baker David A

Abstract excerpt

Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes). Microarray analysis identified glycerol kinase (GK) as the second most highly upregulated gene in Plasmodium falciparum gametocytes with no expression detectable in asexual blood stage parasites. Phosphorylation of glycerol by GK is...

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Animals, Genetically Modified
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Glycerol
Oligonucleotide Array Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Protozoan Proteins

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Identifiers

PMID: 19040641
DOI: 10.1111/j.1365-2958.2008.06544.x
PMCID: PMC2680290

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