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The current state of xenotransplantation

7 Dec 2014

Abstract excerpt

Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyperacute rejection (HAR) include α1,3-galactosyltransferase (GGTA1) inactivation, regulation of the complement system...

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PMID: 25487710
DOI: 10.1007/s13353-014-0261-6

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