Article

Combined colon organoid and sensory neuron system predicts moringin efficacy against painful inflammatory bowel disease

2026-03-24

Abstract excerpt

<h4>Background: </h4> and purpose: Visceral pain is a major symptom of inflammatory bowel diseases (IBD), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity. Moringa oleifera constituents show beneficial properties that may counteract inflammation-induced epithelial dysfun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b3e86e3-fc93-585b-8680-160f96e9f08c
DOI: 10.22541/au.176419307.78559719/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combined colon organoid and sensory neuron system predicts moringin efficacy against painful inflammatory bowel diseaseDOI 10.22541/au.176419307.78559719/v2Read

Myricetin suppressed DSS-induced colitis and promoted the therapeutic success of Infliximab in TNBS-induced colitisSemantic proximity Read

IL-17 sensitises sensory neurons and colonic afferents to noxious stimuli in a PI3K dependent mannerSemantic proximity Read

Sensory Neuron Dysfunction in Orthotopic Mouse Models of Colon CancerSemantic proximity Read

Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasisSemantic proximity Read

The Rationale for Sulforaphane to Favourably Influence Gut Homeostasis and Gut-Organ Dysfunction: a Clinician’s HypothesisSemantic proximity Read

Colon Innervating TRPA1 Positive Nociceptors Influence Mucosal Health In MiceSemantic proximity Read

An interorgan neuroimmune circuit promotes visceral hypersensitivitySemantic proximity Read

Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel diseaseSemantic proximity Read

Water Extract of Senecio scandens Buch.-Ham. Ameliorates Allergic Contact Dermatitis by Targeting MrgprB2 and Restoring Sustained Potassium Currents in Dorsal Root Ganglion NeuronsSemantic proximity Read

Comparison of the Different Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Mice in the Enteric Nervous SystemSemantic proximity Read

Differential requirements for Rhubarb in constipation-induced inflammation, disorder of gut microbiome and metabolismSemantic proximity Read

Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndromeSemantic proximity Read