Article

GADD45β Inhibits Hepatic Lipogenesis through the AMPK/SREBP1 Pathway via Reducing the ubiquitination-mediated Degradation of SIRT1

2025-06-27

Abstract excerpt

<title>Abstract</title> <p>Nonalcoholic fatty liver disease (NAFLD) is a globally increasing metabolic disorder associated with serious health complications. The molecular mechanisms linking stress-response proteins to hepatic lipogenesis in NAFLD remain poorly understood. Here, we identify GADD45β as a key suppressor of de novo lipogenesis through stabilization of SIRT1. In both methionine-choline-deficient (MCD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b37bfe8-b4af-5989-a2db-51537affc960
DOI: 10.21203/rs.3.rs-6769255/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GADD45β Inhibits Hepatic Lipogenesis through the AMPK/SREBP1 Pathway via Reducing the ubiquitination-mediated Degradation of SIRT1DOI 10.21203/rs.3.rs-6769255/v1Read

Enpp1 ameliorates NAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathwaySemantic proximity Read

Metformin's Effect on Non-Alcoholic Fatty Liver Disease through the miR-200a-5p and AMPK/SERCA2b PathwaySemantic proximity Read

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Semantic proximity Read

Hepatic miR-93 promotes the pathogenesis of metabolic dysfunction-associated steatotic liver disease by suppressing SIRT1Semantic proximity Read

Regulation of fatty acid oxidation by liraglutide via SIRT1 in hepatocytes: A mechanistic studySemantic proximity Read

NPAS2 Promotes MASLD and Hepatocarcinogenesis through SIRT1-Mediated PPARγ SuppressionSemantic proximity Read

Mammalian Ste20-Like Kinase 1 Regulates AMPK to Mitigate the Progression of Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read

GCN5 drives NAFLD progression through LXRα/SREBP1c signaling pathway-mediated de novo lipogenesisSemantic proximity Read

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver DiseaseSemantic proximity Read

PDIA4: A Novel ER Stress Protein Regulating Hepatic Lipogenesis in Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read

Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesisSemantic proximity Read

Exercise ameliorates sarcopenia and metabolic dysfunction–associated steatohepatitis through activation of skeletal muscle PGC-1α/SIRT1 signaling in miceSemantic proximity Read