Article

Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer

2022-10-13

Abstract excerpt

Many regions in the human genome vary in length among individuals due to variable numbers of tandem repeats (VNTRs). We recently showed that protein-coding VNTRs underlie some of the strongest known genetic associations with diverse phenotypes. Here, we assessed the phenotypic impact of VNTRs genome-wide, 99% of which lie in non-coding regions. We applied a statistical imputation approach to estimate the lengths o...

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Literature Corpus work: 9acf91fd-b12c-514c-b1d6-ea141585d8ad
DOI: 10.1101/2022.10.11.22280955

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