Article

A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank

2024-01-23

Abstract excerpt

Most genetic association studies focus on binary variants. To identify the effects of multi-allelic variation of tandem repeats (TRs) on human traits, we performed direct TR genotyping and phenome-wide association studies in 168,554 individuals from the UK Biobank, identifying 47 TRs showing causal associations with 73 traits. We replicated 23 of 31 (74%) of these causal associations in the All of Us cohort. While...

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Literature Corpus work: 8deebbc8-034e-5f0d-865e-798f594d27ec
DOI: 10.1101/2024.01.22.24301630

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