Article

Within-host <i>Mycobacterium tuberculosis</i> evolution: a population genetics perspective

2019-12-04

Abstract excerpt

<h4>ABSTRACT</h4> The within-host evolutionary dynamics of TB remain unclear, and underlying biological characteristics render standard population genetic approaches based upon the Wright-Fisher model largely inappropriate. In addition, the compact genome combined with an absence of recombination is expected to result in strong purifying selection effects. Thus, it is imperative to establish a biologically-releva...

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Literature Corpus work: 9aa8a8bd-8343-546a-8834-997bb5e3f459
DOI: 10.1101/863894

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