Article

Development of a Humanized Anti-Fibrotic Antibody Targeting Extracellular Collagen Assembly to Reduce Post-Traumatic Scarring

2026-04-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Excessive accumulation of fibrillar collagen causes pathological scarring and fibrosis. A promising anti-fibrotic strategy targets the extracellular assembly of collagen fibrils rather than intracellular synthesis pathways. We previously developed a chimeric monoclonal antibody targeting the C-terminal telopeptide of the α2(I) chain of human collagen I that effectively disru...

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Literature Corpus work: 9a9f7fd3-3bc6-5628-917c-ed45cb44940f
DOI: 10.64898/2026.04.20.719618

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