Article

Intra-articular Injection of Hyaluronic Acid and Alpha-2-Macroglobulin to Ameliorate Knee Posttraumatic Osteoarthritis: A Rat Model

2022-07-12

Abstract excerpt

<h4>Background: </h4> Posttraumatic osteoarthritis (PTOA) correlates with a dramatic increase in multiple inflammatory factors after joint injury. There is a broad spectrum proteinase inhibitor known as alpha-2-macroglobulin (A2M) that plays an important role in protecting against inflammatory injury. Endogenous A2M is abundant in serum but insufficient in synovial fluid due to its large molecular weight and has a...

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Literature Corpus work: ae058717-4916-54f6-ac86-0f36c20adb86
DOI: 10.21203/rs.3.rs-1779669/v1

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