Article

Mutations in <i>Drosophila</i> tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia

2021-07-10

Abstract excerpt

Mature tRNAs are generated by multiple RNA processing events, which can include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) complex is responsible for cleaving these intron-containing pre-tRNA transcripts. In humans, TSEN copurifies with CLP1, an RNA kinase. Despite extensive work on CLP1, its in vivo connection to tRNA splicing remains unclear. Interestingly, mutations in CLP1 o...

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Literature Corpus work: 99eac5ab-07dc-59c3-ae50-96236ecd2fd7
DOI: 10.1101/2021.07.09.451847

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