Article

REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM kinase activity

2024-11-03

Abstract excerpt

<h4>Purpose</h4> Repurposing FDA approved drugs with off-target autophagy inhibition such as chloroquine/hydroxychloroquine (CQ, HCQ) has produced modest anticancer activity in clinical trials, due in part, to a failure to define predictive biomarkers that enable the selection of patients that best respond to this treatment strategy. We identified a new role for REDD1 as a determinant of sensitivity to autophagy...

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Literature Corpus work: 99e8f9f0-bdea-5092-9d01-ace2a0a32784
DOI: 10.1101/2024.10.29.620949

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