Article

Down-regulation of Risa Improves Podocyte Injury by Enhancing Autophagy in Diabetic Nephropathy

2021-11-16

Abstract excerpt

<h4>Background: </h4> LncRNA AK044604 (Risa), Sirt1 and GSK3β are autophagy related genes that can play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effect of Risa on Sirt1/GSK3β-induced podocyte injury. <h4>Methods: </h4> Transgenic db/db mice were fed and injected with Risa inhibition of adeno-associated virus by tail vein injection, as well as intraperitoneally injected...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1542c51d-e7ba-5ffe-b631-df23645ef259
DOI: 10.21203/rs.3.rs-989734/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of Risa Improves Podocyte Injury by Enhancing Autophagy in Diabetic NephropathyDOI 10.21203/rs.3.rs-989734/v1Read

The regulatory role of miRNA and lncRNA on autophagy in diabetic nephropathySemantic proximity Read

The TXNIP–mTOR–Autophagy axis in diabetic kidney disease: mechanistic insights and therapeutic implicationsSemantic proximity Read

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signalingSemantic proximity Read

Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signallingSemantic proximity Read

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signalingSemantic proximity Read

Network pharmacology and experimental validation of andrographolide’s renoprotective effects on diabetic nephropathy via AGEs-RAGE signaling and mitophagy pathwaysSemantic proximity Read

Transcriptome analysis of the potential mechanisms regulating autophagy in matrine- treated IMCD3 cellsSemantic proximity Read

DDIT4 mediated autophagy and ferroptosis through VDR-mTOR signaling pathway in the treatment of diabetic kidney diseaseSemantic proximity Read

miR-378a and NPNT coordinate autophagy regulation in podocytes through mTOR and MAPK signalingSemantic proximity Read

The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disordersSemantic proximity Read

The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular DiseasesSemantic proximity Read

Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathySemantic proximity Read