Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibiting autophagy: a novel approach for the treatment of renal cell carcinoma.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Lotze Michael T, Maranchie Jodi, Appleman Leonard

Abstract excerpt

The common clear cell subtype of renal cell carcinoma is associated with hereditary or acquired loss of function of the von Hippel-Lindau tumor suppressor, a key component in oxygen sensing, perpetuating a stressed state. Autophagy is primarily a highly conserved, catabolic process by which stres...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lysosomes
Share to Oxygen
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Clinical Trials as Topic

Share to Genomic Instability

Share to Hydroxychloroquine

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 23867516
DOI: 10.1097/PPO.0b013e31829da0d6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23867516-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibiting autophagy: a novel approach for the treatment of renal cell carcinoma.PMID 23867516Read ↗

Targeting Autophagy in Cancer: Recent Advances and Future Directions.Semantic proximity Read ↗

Role of Autophagy in Renal CancerSemantic proximity Read ↗

Potentials of Small-Molecule Natural Products Against Autophagy Dysfunction in Kidney DiseasesSemantic proximity Read ↗

Non-coding RNAs regulate autophagy in kidney disease: friend or foe?Semantic proximity Read ↗

A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces AutophagySemantic proximity Read ↗

Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy.Semantic proximity Read ↗

Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy InhibitionSemantic proximity Read ↗

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiencySemantic proximity Read ↗

Autophagy induction promotes renal cyst growth in polycystic kidney disease.Semantic proximity Read ↗

Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.Semantic proximity Read ↗

Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2αSemantic proximity Read ↗

REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM kinase activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.