Article

mirCCC: Repression-aware graph learning for miRNA-mediated cell-cell communication inference

2026-07-01

Abstract excerpt

Cell–cell communication analyses usually focus on protein ligands and receptors and therefore miss extracellular vesicle transfer of microRNAs, an important route of signalling in cancer. Here we show that microRNA-mediated communication can be inferred from standard single-cell RNA sequencing by detecting coordinated decreases in the expression of validated miRNA target genes. We developed mirCCC, a computational...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de0252db-a542-52d3-8515-093aeff216ee
DOI: 10.64898/2026.06.26.734694

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

mirCCC: Repression-aware graph learning for miRNA-mediated cell-cell communication inferenceDOI 10.64898/2026.06.26.734694Read

Extracellular vesicle-derived miRNA-mediated cell-cell communication inference for single-cell transcriptomic data with miRTalkSemantic proximity Read

GraphComm: A Graph-based Deep Learning Method to Predict Cell-Cell Communication in single-cell RNAseq dataSemantic proximity Read

Deconvoluting single-cell transcriptomics reveals cellular programs regulated by cell-cell communication in colorectal cancerSemantic proximity Read

Comparative analysis of cell-cell communication at single-cell resolutionSemantic proximity Read

ICELLNET: a transcriptome-based framework to dissect intercellular communicationSemantic proximity Read

Mathematically mapping the network of cells in the tumor microenvironmentSemantic proximity Read

collectNET: a web server for integrated inference of cell-cell communication networkSemantic proximity Read

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor CharacteristicsSemantic proximity Read

Patient-specific cell communication networks associate with disease progression in cancerSemantic proximity Read

IntraTalker - Modelling Intracellular Signalling in Cellular CrosstalkSemantic proximity Read

Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan–Glycolysis Coupling in Cisplatin-Resistant HGSOCSemantic proximity Read

Understanding cell‐cell communication and signaling in the colorectal cancer microenvironmentSemantic proximity Read