Article

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

2024-02-26

Abstract excerpt

Cells exist in highly crowded environments where they are exposed to fluctuating mechanical forces arising from surrounding cells and the extracellular matrix microenvironment. In these settings, external forces are transmitted to intracellular organelles including the nucleus. While cells can survive confinement, extended duration of confinement or confinement in settings where cells are unable to escape, can res...

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Literature Corpus work: 99d73670-ca64-5c2a-9cdd-42497ca60467
DOI: 10.1101/2024.02.23.581510

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