Article

Targeting the SARM1–cADPR–Ca²⁺ Pathway Attenuates Mitochondrial Fragmentation and Osteoarthritis Progression

2026-02-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction</bold> : Osteoarthritis (OA) is a prevalent degenerative joint disease accompanied by increased number of senescent chondrocytes. Mitochondrial dysfunction is a well-established hallmark of chondrocyte senescence in OA pathogenesis. Sterile α and Toll/Interleukin-1 Receptor motif–containing 1 (SARM1), known to drive mitochondrial impairment in various cell types, h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7172febb-4bf9-502a-b79b-6d4a2d2277f1
DOI: 10.21203/rs.3.rs-8664870/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting the SARM1–cADPR–Ca²⁺ Pathway Attenuates Mitochondrial Fragmentation and Osteoarthritis ProgressionDOI 10.21203/rs.3.rs-8664870/v1Read

Correlation between Mitochondria-Associated Endoplasmic Reticulum Membrane-Related Genes and Cellular Senescence-Related Genes in OsteoarthritisSemantic proximity Read

Unraveling the path to osteoarthritis management: targeting chondrocyte apoptosis for therapeutic interventionSemantic proximity Read

Mitochondria: Potential Targets for OsteoarthritisSemantic proximity Read

Mitochondrial Role on Cellular Apoptosis, Autophagy, and Senescence during Osteoarthritis PathogenesisSemantic proximity Read

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatoninSemantic proximity Read

Mechanical confinement induces ferroptosis through mitochondrial dysfunctionSemantic proximity Read

Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degenerationSemantic proximity Read

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of actionSemantic proximity Read

CDKN1A regulation on chondrogenic differentiation of human chondrocytes in osteoarthritis through single-cell and bulk sequencing analysisSemantic proximity Read

Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.Semantic proximity Read

A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasisSemantic proximity Read

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in OsteoarthritisSemantic proximity Read