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Article

Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo.

PLoS genetics - 1 Sept 2011

Stottmann Rolf W, Turbe-Doan Annick, Tran Pamela, Kratz Lisa E, Moran Jennifer L, Kelley Richard I, Beier David R

Abstract excerpt

We describe the rudolph mouse, a mutant with striking defects in both central nervous system and skeletal development. Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase 7, which is an intriguing finding given the recent implication of oxysterols in mediating intracellular Hedgehog (Hh) signaling. We see an abnormal sterol profile and decreased Hh target gene...

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Identifiers

PMID: 21912524
DOI: 10.1371/journal.pgen.1002224
PMCID: PMC3164675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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