Article

Regulation of CYP3A genes by glucocorticoids in human lung cells

2013-10-08

Abstract excerpt

Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma. However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung. CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes. However, the mechanism of CYP3A5 mRNA regulatio...

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Literature Corpus work: 99a0be87-3d00-5bd3-ba0f-8e252bf74ebc
DOI: 10.12688/f1000research.2-173.v2

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