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Targetable genomic profiling of breast cancer brain metastases identifies alterations and genomic signatures relevant to immune-checkpoint and PARP inhibitors

2024-04-26

Abstract excerpt

<title>Abstract</title> <p>Introduction: Understanding the genomic landscape of breast cancer brain metastases (BCBMs) is key to developing targeted treatments. Materials and Methods In this study, targetable genomic profiling was performed on 822 BCBMs, 11,988 local breast cancer (BC) biopsies and 15,516 non-central nervous system (N-CNS) metastases (all unpaired samples) collected during the course of routine...

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Literature Corpus work
997c533d-6437-5a6b-8b84-2b683dad390a
DOI
10.21203/rs.3.rs-4206376/v1
Open publication

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