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Article

Comprehensive genomic profiling to identify actionable alterations for breast cancer brain metastases in the Chinese population.

ESMO open - 1 Mar 2024

Lu Q, Wang N, Jiang K, Zhou H, Zhang P, Zhang J, Wang S, Sun P, Xu F

Abstract excerpt

BACKGROUND: Breast cancer brain metastasis (BCBM) is a crucial issue in the treatment of breast cancer and is associated with poor prognosis. Therefore, novel therapeutic targets are urgently needed in clinical practice. In this study, we aimed to identify potential actionable targets in brain metastases (BMs) utilising the FoundationOne® CDx (F1CDx). PATIENTS AND METHODS: Formalin-fixed paraffin-embedded...

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Identifiers

PMID: 38460250
DOI: 10.1016/j.esmoop.2024.102389
PMCID: PMC10940923

Genes

CCND1
ATM
BRAF
BRCA2
ERBB2
FGF19
FGF3
FGFR1
KIT
PIK3CA
PTEN
RAD21
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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